文献分享抗TNF治疗可用于不育症和
很多意外发现都是大胆尝试,偶然发现! 今天与大家分享的是一篇年发表在AmericanJournalofReproductiveImmunology《美国生殖免疫学杂志》的一篇解说词文章 以下是MEDsci的资讯网查询出的有关该杂志的介绍 该文章的题目:ShouldAnti-TNF-aTherapybeOfferedtoPatientswithInfertilityandRecurrentSpontaneousAbortion?* 不育和复发性自然流产患者是否应应用抗TNF-α治疗? Introduction 前言 Tumornecrosisfactor-alpha(TNF-α)isapro-in?ammatorycytokinethatisgoodforyou.Inphysiologicalhomeostasis,itparticipatesinin?ammation,defenseagainstinfection,andpossibly,actsasananti-tumoragent.Excessivelevelswhichoccursystemicallyasacytokinestormmosttypicallyassociatedwithsepsis,orlocallyatthefemalepelvisasinendometriosisandembryoloss,mayleadtopathology.ThepaperinthisissueofAJRIbyWingeretal.suggeststhatantagonizingTNF-αinasubsetofpatientswithIVFETfailuremaydramaticallyimprovesuccessrates.AsimilarpaperintheJulyissueofAJRIindicatedabene?toftreatmentincoupleswithunexplainedrecurrentspontaneousabortion(RSA).Thelatterpublicationwasac |
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